Digital gene expression analysis of transcriptomes in lipopolysaccharide-induced acute respiratory distress syndrome

•Mouse model of LPS-mediated ARDS was successfully replicated.•The lung RNA samples were used for digital gene expression analysis.•More than 2000 differentially expressed genes were identified.•1858 differentially expressed genes were significantly enriched for Gene Ontology.•2259 differential expression genes were involved in 216 KEGG pathways.