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Caged ligands to study the role of intracellular GPCRs

Artavazd Tadevosyan,Louis R. Villeneuve,Alain Fournier,David Chatenet,Stanley Nattel,Bruce G. Allen

Methods（2016）

Cited 12|Views11
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Abstract
•Caged Ang-II shows lower affinity towards AT1R and AT2R.•Caged Ang-II is more cell-permeable than Ang-II.•Caged Ang-II allows selective activation of nuclear ATRs.•Nuclear ATR activation produces a greater change in [Ca2+]n that cell surface ATRs.
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AT1R,AT2R,ACE,DMNB,PACAP(28–38),TAT(48–60),UV
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