Back Cover: Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor (ChemMedChem 2/2012)

Chienhuang Wu,Chunping Chang,Jenshin Song,Jiingjyh Jan,Mingchen Chou,Kaichia Yeh,Yingchieh Wong,Chiehjui Hsieh,Chiungtong Chen,Tzuting Kao,Suying Wu,Chingfang Yeh,Chentso Tseng,Y Chao,Kakshan Shia

ChemMedChem（2012）

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Abstract

The back cover picture shows a novel CXCR4-targeted antagonist blocking the SDF-1/CXCR4 interaction, resulting in mobilization of various stem cells, particularly the CD34+ cell type, from the bone marrow to the peripheral blood circulating system. Hematopoietic stem cells thus collected can be potentially applied to autologous transplantation to help cancer patients restore their immune system rapidly after undergoing chemo- or radiotherapy. For more details, see the Communication by Kak-Shan Shia et al. on p. 209 ff.

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Key words

cxcr4,chemokines,gpcrs

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