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Radiosynthesis of 4-[ 18 F]fluoro-l-tryptophan by isotopic exchange on carbonyl-activated precursors

Philipp S Weiss,Johannes Ermert,Johnny Castillo Melean, Dominique Schafer,Heinz H Coenen

Bioorganic & Medicinal Chemistry（2015）

Cited 18|Views10
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Abstract
4-[18F]Fluoro-l-tryptophan was synthesized by isotopic exchange, followed by removal of the formyl group with Rh(PPh3)3Cl and subsequent simultaneous hydrolysis of the protecting groups.
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Key words
Aromatic amino acids,4-Fluoro-l-tryptophan,Fluoroindoles,Fluorine-18,Radiofluorination,Isotopic exchange
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