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Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane

Tomoya Yamamoto,Yuichi Umegawa,Hiroshi Tsuchikawa,Nobuaki Matsumori,Shinya Hanashima,Michio Murata,Resul Haser,Bernard J. Rawlings,Patrick Caffrey

Bioorganic & Medicinal Chemistry（2015）

Cited 11|Views3
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Abstract
Additional hydroxy-bearing AmB were prepared from bioengineered 7-oxo AmB. Their efficacy and sterol selectivity in K+ flux assays revealed the importance of intramolecular hydrogen bonds in the rigidity of the macrolactone ring.
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AmB,BCECF,COSY,FCCP,HSQC,NOESY,POPC,SAR
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