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Preparation and Biological Evaluation of Conformationally Constrained BACE1 Inhibitors

Leonard L. Winneroski,Matthew A. Schiffler,Jon A. Erickson,Patrick C. May,Scott A. Monk,David E. Timm,James E. Audia,James P. Beck,Leonard N. Boggs,Anthony R. Borders,Robert D. Boyer,Richard A. Brier,Kevin J. Hudziak,Valentine J. Klimkowski,Pablo Garcia Losada,Brian M. Mathes,Stephanie L. Stout,Brian M. Watson,Dustin J. Mergott

Bioorganic & Medicinal Chemistry（2015）

引用 17|浏览61
关键词
BACE inhibitor,Complex organic synthesis,Conformational constraint,Stereoselective,Structure-based drug design
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