Hemorheological study in a group of patients with clinically silent multifocal vascular cerebral lesions

Clinically silent vascular cerebral lesions/CSVCL /INS;have been a problem of great importance in neurology. It involves patients with risk factors for stroke such as hypertension, diabetes mellitus, and /INS;cardiac diseases with arrhyth/INS;mia but our knowledge about the path/INS;omechanism of these changes has not been clear enough/INS;. We analysed hemorheological profile in a group of 35 patients with CSVCL diagnosed by magnetic resonance imaging or computed tomography in relation to the control group/10 subjects without such changes. The following hemorheological parameters were estimated: relative blood viscosity at various shear rates, plasma viscosity, haematocrit and parameters of Quemada'/INS;s rheological model (/INS;RCD as red cell deformability and RCA as red cells aggregation)/INS;. We also estimated biochemical factors: fibrinogen, IgM, IgG, IgA, CRP, cholesterol and albumin/globulin ratio [A/G]. We found a significant increase of red cell elasticity (/INS;p < 0,04) /INS;in a group of patients as well as a significant decrease of IgM level (/INS;p < 0./INS;018)/INS;, cholesterol (/INS;p < 0./INS;04) /INS;and A/G (/INS;p < 0./INS;036)/INS;. We detected also the following significant correlations: between A/G and RCA/negative in patients, p < 0./INS;05, cholesterol and RCA/positive in controls, p < 0./INS;007, IgM and/INS; fibrinogen/negative in both groups, p < 0./INS;04 and p < 0./INS;01 respectively, IgM/fibrinogen ratio and RCA/negative in patients, p < 0./INS;02, cholesterol and fibrinogen/positive in patients, p < 0,035. In conclusion we may suggest that a better red cell elasticity in patients results from a self-regulatory compensation. IgM molecules seem to play an opposite role to fibrinogen molecules in red cells aggregation phenomenon.