A miniaturized readout strategy for endogenous histone deacetylase activity
MOLECULAR BIOSYSTEMS（2015）
Abstract
Histone deacetylases are important drug targets, which are difficult to characterize due to their poor accessibility. We have developed a miniaturized assay for the multi-site readout of deacetylase activity and profiled the substrate selectivity of HDACs for acetylation sites on histone H4 and tumor suppressor protein p53.
MoreTranslated text
Key words
histone,miniaturized readout strategy
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined