Taregting acylcarnitine content in vascular tissue to attenuate development of atherosclerosis
Atherosclerosis(2015)
摘要
Objective: The increase in the tissue and plasma pools of acylcarnitines, esters of fatty acid and L-carnitine, have been linked to the disturbed energy metabolism and development of type 2 diabetes mellitus. Methyl-γ-butyrobetaine (methyl-GBB) is a potent inhibitor of L-carnitine biosynthesis and transport, which lowers acylcarnitine content in heart tissues. In this study, the effects of methyl-GBB on the progression of atherosclerosis and the levels of acylcarnitines in vascular tissues were evaluated.
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关键词
acylcarnitine content,atherosclerosis,vascular tissue
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