ChemInform Abstract: Synthesis and anti-Trypanosoma cruzi Activity of β-Lapachone Analogues.

Sabrina Baptista Ferreira,Kelly Salomao,Fernando de Carvalho da Silva,Antonio Ventura Pinto,Carlos Roland Kaiser,Angelo C. Pinto,Vitor Francisco Ferreira,Solange L. de Castro

Cheminform（2011）

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摘要

The naphthoquinone analogues of β-lapachone are obtained from methylene and aryl o-quinone methides, generated in situ by Knoevenagel condensation of lawsone (I) with paraformaldehyde (II) or aryl aldehydes (IX), followed by hetero Diels—Alder reaction with different dienophiles.

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anti-trypanosoma

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