ChemInform Abstract: Iridium‐Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead‐Like Molecular Properties.

Paolo Tosatti,Joachim Horn,Amanda J Campbell,David House,Adam Nelson,Stephen P Marsden

Cheminform（2011）

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摘要

The combination of an air-stable iridium catalyst and the dipolar aprotic solvent dimethyl sulfoxide (DMSO) allowed, for the first time, the systematic exploitation of highly polar, functionalized amines in asymmetric allylic substitutions: low molecular weight, sp(3)-rich chiral building blocks were obtained with physicochemical properties that will be valuable in the synthesis of lead-like small molecules.

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关键词

allylic compounds,allylic substitution,asymmetric catalysis,iridium,lead-like compounds

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