ChemInform Abstract: New Chiral Ferrocenyl P,S‐Ligands for Highly Diastereo‐ and Enantioselective Ag(I)‐Catalyzed Asymmetric [3 + 2] Cycloaddition of Azomethine Ylides.

A new family of chiral ferrocenyl p,s-ligands incorporating an indole ring at the alpha-ferrocenylmethyl position has been prepared via a friedel-crafts alkylation reaction of (r-c,s-fc)-ppfa with a variety of 2-indole thioethers. these newly developed ferrocenyl p,s-ligands proved to be efficient in the agoac-catalyzed asymmetric [3+2] cycloaddition of azomethine ylides with various dipolarophiles, giving cycloadducts with high diastereoselectivities and enantioselectivities (up to 99% ee). (c) 2012 elsevier ltd. all rights reserved.