ChemInform Abstract: One‐Pot Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles via Huisgen 1,3‐Dipolar Cycloaddition Catalyzed by SiO2—Cu(I) Oxide and Single Crystal X‐Ray Analysis of 1‐Benzyl‐4‐phenyl‐1H‐1,2,3‐triazole.

A one-pot synthesis of 1,4-disubstituted 1,2,3triazoles via Huisgen 1,3-dipolar cycloaddition reaction between terminal alkynes, benzyl/allyl/alkyl halides, and NaN3 in water at room temperature using silica-supported copper(I) oxide (SiO2–Cu2O) has been developed. Various supported copper(I) oxide catalysts have been tested for this reaction where silica-supported copper(I) oxide works well in this reaction. The catalyst being heterogeneous can be easily recovered at the end of reaction and can be reused making the process completely economical. A single crystal X-ray analysis of 1-benzyl-4-phenyl-1H-1,2,3-triazole has revealed that the compound crystallizes in the monoclinic space group P21.