Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20

Dan Han,Weirong Fang, Rui Zhang,Jie Wei,Nandani Darshika Kodithuwakku,Lan Sha,Wenhuan Ma,Lifang Liu,Fengwen Li,Yunman Li

Brain, Behavior, and Immunity（2016）

引用 34|浏览5

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摘要

•Systemic inflammatory challenges aggravated ischemic stroke in rats.•AR suppressed excessive inflammation caused by I/R superimposed on LPS in rats.•A20 was over-expressed in response to H/R+LPS injury in rBMECs.•AR restored BBB dysfunction induced by H/R coexisting with LPS via up-regulating A20.

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关键词

Clematichinenoside,Blood brain barrier,Systemic inflammation,Ischemic stroke,Zinc finger protein A20,NF-κB

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