Development of LC–MS method for analysis of paclitaxel-inhibited growth and enhanced therapeutic response in human glioblastoma cells

Caihou Lin,Xuexia Lin,Ling Lin,Junming Wang,Zhixiong Lin,Jinming Lin

Chinese Chemical Letters（2015）

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摘要

Paclitaxel usually binds to microtubules of SU3 glioma cells, and thus enhanced the cytotoxic response of SU3 glioma cells to temozolomide. This study developed a LC–MS platform to reveal the molecular mechanism of paclitaxel-inhibited growth and enhanced therapeutic response in the chemotherapy for glioma multiforme.

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关键词

LC–MS,Drug analysis,SU3 glioma cell,Paclitaxel,Cell cycle arrest,ROS assay

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