KMT2 family of H3K4 methyltransferases: enzymatic activity-dependent and -independent functions

Hieu T. Van,Guojia Xie,Peng Dong,Zhe Liu,Kai Ge

Journal of Molecular Biology（2024）

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摘要

•KMT2 methyltransferases are responsible for methylation on H3K4.•KMT2 family include six members: KMT2A/B, KMT2C/D, and KMT2F/G.•KMT2s play important roles in gene regulation, differentiation, and development.•KMT2 methyltransferases have enzymatic activity-dependent and independent functions.

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关键词

KMT2,MLL,H3K4 methyltransferases,gene regulation,organism development

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