Evaluation of invitro α-amylase and α-glucosidase inhibitory potential of N 2 O 2 schiff base Zn complex

The evaluation of the antioxidant, antibacterial and enzyme inhibition effects of N2O2 Schiff base Zn complex was investigated. The percentage scavenging activity of hydroxyl radical (IC50-0.21μg), ABTS (IC50-0.19μg) and DPPH (IC50-0.25μg) shows that ZnL complex had a potential antioxidant activity. The antibacterial activity of ZnL complex was evaluated. Results showed that MIC value against Staphylococcus aureus and Salmonella typhi was 100 and 200μg/ml, respectively. ZnL complex showed strong inhibition toward α-amylase and α-glucosidase with an IC50 value of 0.18 and 0.23μg, respectively. The inhibition mechanism was analyzed with LB and Dixon plots. The ZnL complex could be a mixed noncompetitive and noncompetitive inhibitor with Ki values of 77.8 and 31.6μg for α-amylase and α-glucosidase, respectively. The preliminary assessment of ZnL complex showed that they can be used as an antioxidant, antibacterial and antidiabetic agents.