Polycomb recruitment at the Class II transactivator gene

•Epigenetic mechanisms behind CIITA gene inducibility are poorly described.•YY1 and JARID2 are binding partners with EZH2 and influence PRC2 activity.•YY1 dissociates and JARID2 increases binding to CIITA promoter upon activation.•Novel proteins involved in PRC2 recruitment at CIITA promoter have been described.