Anti-DNA antibody mediated catalysis is isotype dependent
Molecular Immunology(2016)
摘要
•Catalytic activities of anti-DNA antibodies are not only a function of the variable region, but are also isotype dependent.•DNA cleavage and proteolysis by anti-DNA antibodies increase with incubation time and temperature.•The design of antibodies for therapeutic purposes should include consideration of the catalytic effects contributed by the antibody constant region.
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关键词
AHS,ALW,ds,ELISA,mAb,NMR,SLE,SPR
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