The nonstructural protein 11 of porcine reproductive and respiratory syndrome virus inhibits NF-κB signaling by means of its deubiquitinating activity

Dang Wang,Jinxiu Fan,Liurong Fang,Rui Luo,Haiping Ouyang,Chao Ouyang,Huan Zhang,Huanchun Chen,Kui Li,Shaobo Xiao

Molecular Immunology（2015）

Cited 34|Views9

No score

Abstract

•PRRSV Nsp11 possesses DUB activity.•Nsp11 specifically cleave K48-linked, but not K63-linked polyubiquitin chains.•DUB activity is responsible for the ability of Nsp11 to inhibit NF-κB activation.

Translated text

Key words

Porcine reproductive and respiratory syndrome virus,Nonstructural protein 11,Deubiquitinating activity,NF-κB

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined