Potent anti-Toxoplasma gondii activity of 4-chlorophenylthioacetone-derived thiosemicarbazones: Involvement of CCR2 and CCR5 receptors and 5-lipoxygenase in the mode of action

Rayane Aparecida Nonato Rabelo,Diego Rodney Rodrigues de Assis,Alexandre Almeida Oliveira,César Luís Nascimento Barbosa,Rafaela das Dores Pereira,Ricardo Wagner de Almeida Vitor,Wiliam César Bento Régis,Mauro Martins Teixeira,Heloísa Beraldo,Fabiana Simão Machado

Medicine in Drug Discovery（2023）

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Abstract

•Thiosemicarbazones Ca and Cb represent potent anti-Toxoplasma drug candidates.•Ca and Cb attenuate Toxoplasma gondii (Tg) growth in macrophages and glial cells.•Compounds control Tg replication acting on the parasite in infected host cells.•Ca and Cb possess potent anti-Toxoplasma activity in vitro and in vivo.•Compounds increase cytokine production and raise the survival rate of Tg-infected mice.

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Key words

Toxoplasma gondii,Toxoplasmose,Thiosemicarbazones,Macrophages,Immune response

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