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NDRG1 overexpressing gliomas are characterized by reduced tumor vascularization and resistance to antiangiogenic treatment

Thomas Broggini, Marie Wustner,Christoph Harms,Lena Stange,Jonas Blaes,Carina Thome,Ulrike Harms,Susanne Mueller,Markus Weiler,Wolfgang Wick,Peter Vajkoczy,Marcus Czabanka

Cancer Letters（2016）

Cited 17|Views22
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Abstract
•We examined the role of NDRG1 for glioma angiogenesis in an orthotopic glioma model.•High NDRG1 expression in gliomas show reduced angiogenesis.•High NDRG1 expression in gliomas results in upregulation of the angiogenesis inhibitor TNFSF15.•High NDRG1 expression in gliomas reduces the responsiveness to antiangiogenic therapy.
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Key words
Glioma angiogenesis,Antiangiogenic treatment,Resistance to antiangiogenesis,Glioma microcirculation,TNFSF15,NDRG1
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