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mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells

Govindasamy-Muralidharan Karthik,Ran Ma,John Lövrot,Lorand Levente Kis,Claes Lindh, Lennart Blomquist,Irma Fredriksson,Jonas Bergh,Johan Hartman

Cancer Letters（2015）

Cited 45|Views22
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Abstract
•Tamoxifen activates translation process in patient derived breast cancer stem cells.•mTOR downstream targets are activated in CSC and are further enhanced by tamoxifen.•mTOR inhibition attenuates tamoxifen induced translation process in CSCs.
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Breast cancer stem cells,Tamoxifen resistance,mTOR pathway activation
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