Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice

Chrysovalantou E Xirouchaki,Salvatore P Mangiafico,K Bate,Z Ruan,Amy M Huang, Bing Wilari Tedjosiswoyo,B J Lamont, Wynne Pong,Jenny Favaloro,Amy R Blair,Jeffrey D Zajac,Joseph Proietto,Sofianos Andrikopoulos

Molecular Metabolism（2016）

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摘要

•Muscle-specific gys1 knockdown in adult mice results in 70% reduction in skeletal muscle glycogen levels.•Muscle-specific gys1 knockdown leads to glucose intolerance and peripheral insulin resistance.•Muscle glycogen depletion caused impaired performance, as well as fatigue development during exercise.

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关键词

gys1,Glucose tolerance,Insulin sensitivity,Muscle glucose uptake,Exercise capacity,Inducible muscle-specific knockout (KO) mice

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