Re-treatment with Y-90 glass microspheres after unsuccessful radioembolization with Y-90 resin spheres

1449 Objectives Early changes in perfusion or stasis during radioembolization (RE) with resin microspheres, SIR-spheres (SS), can lead to significant reduction in intratumoural radiation doses, which in turn may cause inadequate treatment response. We investigated the implementation and feasibility of RE with glas microspheres, TheraSphere (TS), in non-responders after unsuccessful RE with SS due to early flow changes. Methods The definition of technical failure was set at Results There was significant reduction of SUV parameters (ΔSUVmax, ΔT/L Ratio) after TS compared to baseline (p Conclusions Re-treatment with low-embolic RE using TS may provide a safe and effective option after flow-related technical failure of SS. Larger patient numbers and supplemental data are needed to confirm these promising preliminary results.