Asymmetric Allylic Alkylation Catalysed By Iridium

The most advanced work in the iridium-catalysed allylic alkylation is reviewed herein. Particular emphasis is given to the use of stabilised nucleophiles with catalyst C2, which allows the reaction of a wide range of electrophiles and nucleophiles. High regio- and enantioselectivities are obtained together with improved kinetics. The role of the - OMe substituents is discussed as well as the synthetic applications of this catalyst system.