Silicone containing biomaterials in cardiovascular applications

A series of biostable polyurethane (PU) formulations, including a composite containing a biocompatible clay as filler, were prepared as new biomaterials for cardiovascular applications. Polydimethylsiloxane (PDMS) and polytetramethylenoxide (PTMO) were selected as macrodiols because of their high hydrolysis resistance(1). 1,6-Diisocyanatohexane (HDI) and 1,4-cyclohexane dimethanol (CDM) were used as diisocyanate and chain extender, respectively. Chemical and mechanical characterizations of the obtained polymers highlight that they are promising materials for applications in the cardiovascular field.