Injection Sclerotherapy (Endoscopic Embolization) for Esophageal Varix
Japanese Journal of Hospital Pharmacy(1984)
Abstract
In our previous report(lst Report), study was made on the stability of an injectable solution (EOMA) to be used in injection sclerotherapy (endoscopic embolization) for esophageal varix, which was prepared by mixing Ethanolamine Oleate Injection (EO) with a contrast medium, meglumine amidotrizoate injection.In the present study (2nd Report), another injectable solution (EOI) was prepared by mixing EO with non-ionic iopamidol injecion. With sterilized and unsterilized samples of EOI, observation was made on time-course changes in appearance, pH and the volume of each component for 8 weeks. Also, mucosity and osmotic pressure of EOI, EO and EOMA were measured.Except for slight development of a brown color in sterilized samples of EOI, no major change was observed in each test item during the 8-week storage in a dark and cold place. The results suggest that EOI is stable for at least 8 weeks in a dark, cold place. As the mucosity of EOI is lower than that of EOMA, EOI has great advantages in the filtration operation in manufacturing process of injections or in injection into affected parts.
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Key words
endoscopic embolization,injection
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