The Use of Diffusion Weighted Imaging in the Diagnosis of Intraocular Relapse of Acute Lymphoblastic Leukemia: A Case Report

Intraocular relapse of Acute Lymphoblastic Leukemia (ALL) is rare. Prompt diagnosis and treatment can minimize vision loss. We report a case of a young girl diagnosed with pre-B ALL who was initially treated successfully with chemotherapy. She presented 2½ years after completion of therapy with unilateral vision changes. Using Magnetic Resonance Imaging (MRI) with diffusion Weighted Imaging (DWI), we localized the intraocular lesions and suspected a malignant lesion. Further studies confirmed Central Nervous System (CNS) relapse of ALL. This report supports the use of DWI in differentiating benign and malignant lesions of the globe, and in our case, intraocular relapse of ALL.