Clinical trials in near infrared fluorescence imaging with IRDye 800CW
Proceedings of SPIE（2015）
Abstract
A monofunctional, heptamethine dye, IRDye (R) 800CW, is being manufactured under GMP conditions for use in human clinical trials. When attached to a suitable targeting agent and paired with an appropriate camera system, the dye allows Near Infrared (NIR) fluorescence imaging of tumor tissue during surgery. The talk will describe the properties of the dye and give an overview of current and planned clinical trials in Europe and the USA. The dye is available in both the NHS ester and carboxylate forms for conjugation to targeting molecules. A GMP toxicology study of the dye was described in a previous publication.
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Key words
image guided surgery,in vivo imaging,fluorescence,infrared,NIR,IRDye,800CW
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