Hypoglycemic and Hypolipidemic Effects of Melastoma dodecandrum ethanol-extract on Type 2 Diabetic Rats

To observe hypoglycemic and hypolipidemic effects of Melastoma dodecandrum ethanol-extract on type 2 diabetic rats. Except twelve SPF SD rats were as the control group, the rest eighty type 2 diabetic rats were induced by feeding with high-fat and high-sugar diet and intraperitoneal injection of low-dose streptozotocin (STZ, 35mg.kg(-1)). According to the values of blood glucose concentration (>= 11.1 mmol.L-1), the rats were randomly divided into diabetic model group, three Melastoma dodecandrum ethanol-extract groups of high dose (40g.kg(-1)), medium dose (20g.kg(-1)) and low dose (10g.kg(-1)), and positive control group (glibenclamide, 0.30mg.kg(-1)). During 36 d of continuous intragastric (ig) administration, body weights of the rats were measured weekly, the values of fasting blood glucose (FBG) concentration were measured on 7, 14, 21, 28, 35 d after administration. After the last administration, fasting 10 h, then, the rats were decapitated after anesthesia. Blood of the rats were collected for the analysis of serum insulin(INS), total cholesterol(TC), triglycerides(TG) and low density lipoprotein (LDL-C) levels. Compared with the control group, FBG of model group rats were significantly increased (P<0.01). After administration 21 d, compared with the model group, FBG of Melastoma dodecandrum ethanol-extract groups of high dose and medium dose were significantly lower(P<0.01 or 0.05); after administration 28 d, compared with the model group, FBG of Melastoma dodecandrum ethanol-extract groups of high dose, medium dose, low dose and positive control group were significantly lower (P<0.01 or 0.05). Compared with the control group, INS levels of model group were significantly lower (P<0.01); compared with the model group, INS levels of Melastoma dodecandrum ethanol-extract medium dose group were significantly increased (P<0.05). Compared with the control group, TC, TG and LDL-C levels of model group rats were significantly increased (P<0.01), TG of positive control group was significantly increased(P<0.05). Compared with the model group, TC and LDL-C levels of Melastoma dodecandrum ethanol-extract medium dose group were significantly lower (P<0.05) and TG levels was significantly lower (P<0.01); TG levels of positive control group was significantly lower (P<0.01). Melastoma dodecandrum ethanol-extract can decrease blood glucose, regulate blood lipids in type 2 diabetic rats.