Chronic Lymphocytic Leukemia. From Diagnosis to Treatment Decision

Chronic lymphocytic leukemia is an indolent chronic lymphoproliferation with a highly heterogeneous evolution often burdened by difficult unmanageable relapses. Complete clinical and laboratory investigations since the debut contribute significantly to choosing the most appropriate therapeutic option and the time of initiation of specific treatment. Classical chemotherapeutic schemes have proven their effectiveness in time. Completing or changing them with new therapeutic agents, while improving investigative techniques, led to a significant increase in the percentage of achieved complete remission and survival without disease progression. A rigorous monitoring of patients both during treatment and post-chemotherapy, the detection of minimal residual disease, early detection increases the chance of relapse or unresponsive cases. Second-line therapy instituted properly and on time can provide an extension of survival by getting a new complete remission.