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Inhibitors of cyclic nucleotide phosphodiesterases produced by streptomyces. I. Reticulol, an inhibitor of cyclic nucleotide phosphodiesterases.

Yoshio Furutani,Masao Shimada,Masa Hamada,Tomio Takeuchi,Hamao Umezawa

AGRICULTURAL AND BIOLOGICAL CHEMISTRY（1977）

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Abstract
About 1, 200 microbial cultured filtrates have been screened for inhibition of cyclic nucleotide phosphodiesterases (EC 3. 1. 4. c] prepared from rabbit brains. One of the active agents was isolated and identified as reticulol (6, 8-dihydroxy-7-methoxy-3-metbylisocoumarin).
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Key words
cyclic nucleotide phosphodiesterases,streptomyces,inhibitors,inhibitors
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