Evaluation of in vitro and in vivo antibacterial and antifungal activity of "Camelyn M"

The minimum inhibitory concentration (MIC) of "Camelyn M" active compound obtained from special sort of honey in one of region of Georgia, was determined both by agar and broth dilution methods against some of strains of bacteria and fungy. The antibacterial action of "Camelyn M" was further tested in animal models. "Camelyn M" was seen to possess powerful inhibitory action (0,012-0,150 mu g/mL) against most test bacteria in in vitro studies. In vivo studies showed that the drug offered significant protection (p<0.001) to mice challenged with a virulent bacterium. "Camelyn M" exhibited potent in vitro activities against fluconazole-resistant strains of Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis and Candida krusei, with MICs at which 90% of isolates were inhibited of 0.012 mu g/ml, respectively.