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正常孕妇及妊高征患者血浆中5-羟色胺和5-羟吲哚乙酸含量的测定

任东平,杨琳,殷建清,任琳,杨梦庚,张汉霆

CHINESE JOURNAL OF PERINATAL MEDICINE（1999）

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Abstract
目的 探讨血浆中5-羟色胺(5-HT)和5-羟吲哚乙酸(5-HIAA)与妊高征发病的关系.方法 采用高效液相色谱-电化学检测法测定正常妊娠各期孕妇组及妊高征组血浆中5-HT和5-HIAA含量.结果 正常妊娠各期孕妇组血浆中5-HT含量无显著差异;妊高征组血浆中5-HT含量(70.44±28.69 μg/L)明显高于正常晚孕组(24.96±6.57 μg/L)(P＜0.01);妊高征组血浆中5-HIAA含量(4.11±2.30 μg/L)较正常晚孕组(7.87±1.75 μg/L)明显降低,P＜0.01.结论 孕妇血浆中5-HT含量变化可能与妊高征血管收缩的病理过程有关.
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