A CASE OF GASTRIC CANCER IN VON WILLEBRAND'S DISEASE

A 48-year-old man, who was diagnosed as von Willebrand's disease at the age of 34 years, underwent gastric mass survey and further examination revealed an early gastric cancer in the anterior wall of the middle body. Subtotal gastrectomy with R2 lymph node dissection was performed. Immediately before surgery, DDAVP wa given to the patient with a satisfactory response of the ristocetin cofactor activity (64-112%) and there was no serious hemorrage during the procedure. Immediately after surgery abnormal bloddy discharge from the drain occurred, so heat-treated factor VIII concentrates were administrated. After then postoperative course was uneventful. This appears the first report that radical operation for gastric cancer was successfully carried out in a patient with von Willebrand's disease in Japan.