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Mutations In Ribosomal Proteins: Apoptosis, Cell Competition, And Cancer

Nicholas E. Baker,Abhijit Kale

MOLECULAR & CELLULAR ONCOLOGY（2016）

Cited 9|Views5
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Abstract
Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/C heterozygous cells, or Rp/C heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.
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Key words
apoptosis,cancer predisposition,Drosophila melanogaster,genetic mosaic,ribosomal protein,somatic mutation
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