A novel amino acid site closely associated with the neurovirulence of live, attenuated Japanese encephalitis vaccine (SA14-14-2 strain).

Huan Yang,Fengming Fan,Lina Liu,Jie Liu,Yan Sun, Anping Xie,Xiaoling Shi,Li Liu,Yongxin Yu,Yuhua Li,Yonghong Ge,Xianwu Zeng,Huiqiang Yang

Vaccine（2020）

Cited 5|Views37

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Abstract

•Mutation of 244-site (G → E) enhances the virulence of JEV SA14-14-2 in mice.•JEV E244 (G → E) exhibits different virulence in the context of JE vaccine.•Minor mutations in vaccine cannot be detected by Sanger sequencing.•Minor variants in vaccine do not develop to the dominant population.

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Key words

E244,Japanese encephalitis virus,SA14-14-2,Neurovirulence,Neuroinvasiveness,Safety

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