An Autopsy Case of Frontotemporal Dementia with Motor Neuron Disease
Journal of the Korean Neurological Association(2015)
摘要
Approximately 15% of patients with frontotemporal dementia (FTD) have co-occurring motor neuron disease (MND). FTD-MND cases have frontotemporal lobar degeneration (FTLD)âtransactive response DNA-binding protein (TDP) pathology, which is divided into four subtypes (types A, B, C, and D) based on the morphological appearance, cellular location, and distribution of the abnormal TDP inclusions and dystrophic neurites. We report a patient with FTD-MND whose pathological diagnosis was FTLD-TDP type B. This is the first documented autopsy-confirmed case of FTD-MND in Korea. Key Words: Frontotemporal dementia, Motor neuron disease, Transactive response DNA-binding protein
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关键词
frontotemporal dementia,autopsy case,disease
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