Two Cases of Invasive Aspergillus Sinusitis Showing Orbital Apex Syndrome

Fungal sinusitis is fairly common and often incidentally diagnosed in X-ray or computed tomography imaging (CT). Most cases are largely asymptomatic and noninvasive. In invasive cases, subjects are frequently immunocompromised hosts suffering from diabetes mellitus, using steroids or immunosuppressive drugs, or aged. The invasive fungus destroys tissues, muscles, and bones, occasionally even causing cranial and orbital complications. Such fatal fungal sinusitis requires intensive, appropriative treatment if subjects are to survive. Antifungal drugs have recently been reported to be effective against invasive fungal sinusitis. We present two cases of invasive aspergillus sinusitis showing orbital apex syndrome, both of which were improved using antifungal drugs.