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A potential idiotipic vaccine for the treatment of atherosclerosis based on a chimeric mouse/human anti-sulfated glycosaminoglycans antibody

Yosdel Soto,E Acosta,Livan Delgadoroche, Ana G Perez, N Mesa, Y Alfonso, F Batlle,Maria Becquer,Tania Grinan,V Brito, R Sarduy, F Zayas,Ana Maria Vazquez

ATHEROSCLEROSIS（2015）

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Abstract
Aim–Atherosclerosis is an inflammatory disease triggered by arterial proteoglycans retention of proatherogenic lipoproteins. The aim of this study was to characterize the antiatherosclerotic properties of a chimeric anti-sulfated glycosaminoglycans monoclonal antibody (chP3R99 mAb).
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Key words
potential idiotipic vaccine,atherosclerosis,chimeric mouse/human,anti-sulfated
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