THE ROLE OF MIDTRIMESTER AMNIOTIC FLUID LEPTIN AND ENDOTHELIN-1 LEVELS IN PREDICTION OF PREECLAMPSIA

Objective: We investigated leptin and endothelin-1 levels of amniotic fluid (AF) which was collected during genetic amniocentesis to use these parameters for prediction of preeclampsia.Meterial and methods: The level of leptin and endothelin-1 were measured in the samples of AF which were obtained at 16-20 weeks of pregnancy during genetic amniocentesis. We recorded the patients who developed preeclampsia and who had healthy pregnancy and birth.Results: AF leptin and endothelin-1 levels were significantly increased in the preeclamptic group compared to control group.Conclusion: As we detected increased level of AF leptin and endothelin-1 before preeclampsia symptoms develop we think that these proteins can be used to predict preeclampsia. Thus, early follow up and treatment of preeclampsia could decrease possible complications and related financial expense.