Valores de colinesterasa plasmática y eritrocitaria con ácido 6-6‘-ditiodinicotínico (DTNA) como indicador

A cross-sectional descriptive study using 6-6'-dithiodinicotinic acid (DTNA) as an indicator was performed to calculate the values of plasma cholinesterase (AchP) and erythrocyte (AchE) activity and to standardize them to be used as indicators of occupational risk by exposure to organophosphates and carbamates in the population of the Colombian Coffee Growing Area. This method was chosen because it is an accurate, simple, and nonexpensive alternative: with few interferents it allows measuring both AchP and AchE, it does not have to be corrected with hemoglobin; The DTNA is stable frozen or refrigerated and allows to analyze many samples in a short time. A number of 819 samples from farmers were evaluated. While AchE was significantly higher in people under 45 years and in non-fumigating people, AchP was higher in fumigators; this result is an indicator that the fumigant population is exposed to organophosphates and carbamates on a long-term basis. It is suggested to use as maximum reference values of AchE and AchP 11378 U / L and 10354 U / L, respectively as indicators of occupational intervention.