A polymeric high resolution Pirkle-type chiral stationary phase for GC and SFC

A chiral stationary phase with a silicone backbone and substituted side chains of (S)-N-1-(1-naphthyl)-4-propyloxybenzamide substitution has been introduced for open tubular column GC and SFC. The stationary phase has a broad temperature working range 20-280 degrees C), and provides highly efficient columns (> 3000 plates/meter). One of the key interactions for selectivity is the pi-pi interaction, but the stationary phase can also be used to separate enantiomers without pi electrons. The phase can be used to separate a broad range of compounds, which is demonstrated by the separation of enantiomeric compounds having aromatic rings, amino acid and terpenic alcohol groups. This stationary phase expands the use of Pirkle phases into the field of open tubular column chromatography.