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PS5 - 26. Modulation of GLP-1 secreting L-cells derived from intestinal stem cells

Natalia Petersen,Léon van Gurp,Henner Farin,Stieneke van den Brink,Hans Clevers,Eelco de Koning

Nederlands Tijdschrift voor Diabetologie（2015）

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Abstract
Glucagon-like peptide 1 (GLP-1) is produced by intestinal L-cells, augments insulin secretion and plays an important role in glucose homeostasis. Enhancing endogenous GLP-1 secretion improves glycemic control in patients with type 2 diabetes. However, it is not clear how a change in L-cell number could contribute to circulating GLP-1 levels in physiological conditions and in type 2 diabetes.
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Key words
Glycemic Control,Fibroblast Growth Factor,Insulin Concentration,Glucose Homeostasis,Spatial Orientation
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