First Total Synthesis Of (+/-)-Cycloaltilisin 7 And (+/-)-Poinsettifolin B

Cycloaltilisin 7, isolated from the bud covers of Artocarpus altilis, is a new isoprenyl flavone and has the potential cathepsin K inhibitory activity; while poinsettifolin B is another new geranyl chalcone isolated from the extract of Dorsetenia poinsettifolia, an native cameroonian herb used for the treatment of yaws disease, infection, and other possible skin diseases. Starting from the inexpensive hydroxyl acetophenones and hydroxyl benzaldehydes, the first total syntheses of these two natural products are accomplished with simple and mild conditions. The structures of all new compounds are elucidated by HRMS, H-1 NMR and C-13 NMR spectra.