VLDLの異化過程; 殊に Heparin 投与にみられる変動からみたリポ蛋白相互関係

In the present study, using heparin as the model associated with enhanced lipoprotein lipase activity, we studied the correlation of lipoproteins and the change of apoprotein subunits when catabolism of VLDL was accelerated. 33 male patients with ischemic heart disease, hyperlipidemia, essential hypertension and simple obesity were investigated.Blood samples were drawn following an overnight fast and in 10 min. after heparin Na (10U/kg body weight) injection.The results have been obtained as follows:when VLDL catabolism was accelerated by heparin Na infusion, 1) Following decrease in VLDL-TG, FC and apo CII, CIII groups in VLDL were changed simultaneously and FC in HDL was increased reciprocally.2) The subjects were divided into subgroup according to TC/TG ratio in VLDL.Change of lipid composition in VLDL is similar. However as concerns apoprotein, cholesterol-rich VLDL subgroup has an increase in contribution of HDL apo A-I.