The Impact of the Uighur Medicine Seeds of Nigella Glandulifera Freyn (SNF) on Antitumor and Antioxidant Activity in a S180 and EAC Mouse Tumor Model

Objective: This study was designed to study the antitumor, antioxidant activity and antihypoxia of Uighur medicine Seeds of Nigella glandulifera Freyn (SNF) in the S180 and EAC mice tumor model. Methods: A total of 100 were randomly divided into five groups with 20 animals in each group: control group, model group, Seeds of Nigella glandulifera Freyn ethanol extract (SNFEE) group, Seeds of Nigella glandulifera Freyn water extract (SNFWE) group, cyclophosphamide group. The serum levels of superoxide dismutase (SOD), malonaldehyde (MDA), and glutathione-catalase (GSH-PX) were analyzed, and the mice were also subjected to a hypoxia tolerance test. Their climbing ability was also analyzed. Results: The findings of the study revealed that SNF-treatment leads to an increase in blood serum SOD and GSH-PX levels but a decrease in blood serum MDA levels. Moreover, SNF-treatment enhanced the survival time of mice maintained under hypoxic conditions and improved their mice climbing ability. Conclusion: The results of this study indicate that SNF has obvious antitumor, antihypoxia and antioxidative effects.