Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

Fabrice E. Graf,Nicola Baker,Jane C. Munday,Harry P. de Koning,David Horn,Pascal Mäser

International Journal for Parasitology: Drugs and Drug Resistance（2015）

引用 42|浏览3

暂无评分

摘要

•Expression of AQP2 restores drug susceptibility in a resistant Trypanosoma brucei gambiense isolate.•The AQP2/3 chimera from the resistant isolate does not complement AQP2 deletion.•Hence AQP2/3 chimerization accompanied by loss of AQP2 is the cause of drug resistance.

查看译文

关键词

Human African trypanosomiasis,Sleeping sickness,Trypanosoma brucei gambiense,Drug resistance,Melarsoprol,Pentamidine,Aquaporin,Reverse genetics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要