PS4 - 23. Increased TNF receptor signaling induces non-alcoholic steatohepatitis in mice

Non-alcoholic fatty liver disease (NAFLD) is recognized as the leading cause of chronic liver disease. NAFLD includes a disease spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis. Data from animal and clinical studies indicate that Tumor Necrosis Factor (TNF)-α signaling via its receptor TNFR1 plays a proinflammatory role in the pathogenesis of NAFLD and NASH. However, the exact mechanism that drives the inflammation in NAFLD and NASH remains unclear.