PS4 - 23. Increased TNF receptor signaling induces non-alcoholic steatohepatitis in mice
Nederlands Tijdschrift voor Diabetologie(2015)
Abstract
Non-alcoholic fatty liver disease (NAFLD) is recognized as the leading cause of chronic liver disease. NAFLD includes a disease spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis. Data from animal and clinical studies indicate that Tumor Necrosis Factor (TNF)-α signaling via its receptor TNFR1 plays a proinflammatory role in the pathogenesis of NAFLD and NASH. However, the exact mechanism that drives the inflammation in NAFLD and NASH remains unclear.
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Key words
Wild Type Mouse,Chronic Liver Disease,Liver Fibrosis,Simple Steatosis,Proinflammatory Role
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